反应详情

Hydroxylamine hydrochloride (244 mg, 3.51 mmol), 4-chloropyrimidine-2-carboxaldehyde (500 mg, 3.51 mmol), and sodium acetate (288 mg, 3.51 mmol) were dissolved in dry ethanol (17.5 mL) and transferred to a flame-dried round bottom flask. The reaction was allowed to stir at room temperature for 20 minutes. It was then concentrated under reduced pressure, redissolved in ethyl acetate, and washed with water. The aqueous layer was extracted with ethyl acetate two times. The combined organic layers were dried over magnesium sulfate, filtered, and concentrated under reduced pressure to yield the title compound.

1. customtransferred to a flame-dried round bottom flask
2. concentrationIt was then concentrated under reduced pressure
3. dissolutionredissolved in ethyl acetate
4. washwashed with water
5. extractionThe aqueous layer was extracted with ethyl acetate two times
6. dry with materialThe combined organic layers were dried over magnesium sulfate
7. filtrationfiltered
8. concentrationconcentrated under reduced pressure