4-Chloropyrimidine-2-carbonitrile → HCID 59525709, compound

HRID 386105Notes

Reaction equation

HRID 386105 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Cl[C:23]1[CH:28]=[CH:27][N:26]=[C:25]([C:29]#[N:30])[N:24]=1>>[C:29]([C:25]1[N:26]=[C:27]([NH:1][C:2]2[S:3][C:4]([C:10]3[C:11]([F:21])=[CH:12][C:13]([C:17]([OH:20])([CH3:18])[CH3:19])=[CH:14][C:15]=3[F:16])=[CH:5][C:6]=2[C:7]([NH2:9])=[O:8])[CH:28]=[CH:23][N:24]=1)#[N:30]

Participants

3

Reactant 2

HCID 457874934-Chloropyrimidine-2-carbonitrileHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 59525709HCID 59525709, compound

Procedure

The title compound was prepared as described in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (113 mg, 0.36 mmol) and 4-chloropyrimidine-2-carbonitrile (51 mg, 0.36 mmol) as starting materials.

Sources & evidence

ORD record
ord-2d1c2620bf9243959beec320af523f85
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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