2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525981, compound

HRID 386107Notes

Reaction equation

HRID 386107 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:12][C:11]=2[F:20])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Cl[C:22]1[CH:27]=[CH:26][N:25]=[C:24]([CH:28]([OH:33])[C:29]([F:32])([F:31])[F:30])[N:23]=1>>[F:20][C:11]1[CH:12]=[C:13]([C:16]([OH:19])([CH3:17])[CH3:18])[CH:14]=[CH:15][C:10]=1[C:4]1[S:3][C:2]([NH:1][C:26]2[CH:27]=[CH:22][N:23]=[C:24]([CH:28]([OH:33])[C:29]([F:32])([F:30])[F:31])[N:25]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59526148HCID 59526148, compound

Product 1

HCID 59525981HCID 59525981, compound

Procedure

The title compound was prepared as described in Example 1 using 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (68 mg, 0.23 mmol) and 1-(4-chloropyrimidin-2-yl)-2,2,2-trifluoroethanol (49 mg, 0.23 mmol) as starting materials.

Sources & evidence

ORD record
ord-004b1154fed4407ebd5f5370174c102c
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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