4-Chloro-2-cyclopropylpyrimidine → 2-[(2-Cyclopropylpyrimidin-4-yl)amino]-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

HRID 386111Notes

Reaction equation

HRID 386111 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Cl[C:23]1[CH:28]=[CH:27][N:26]=[C:25]([CH:29]2[CH2:31][CH2:30]2)[N:24]=1>>[CH:29]1([C:25]2[N:26]=[C:27]([NH:1][C:2]3[S:3][C:4]([C:10]4[C:11]([F:21])=[CH:12][C:13]([C:17]([OH:20])([CH3:18])[CH3:19])=[CH:14][C:15]=4[F:16])=[CH:5][C:6]=3[C:7]([NH2:9])=[O:8])[CH:28]=[CH:23][N:24]=2)[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 249037134-Chloro-2-cyclopropylpyrimidineHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 595257422-[(2-Cyclopropylpyrimidin-4-yl)amino]-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Procedure

The title compound was prepared by using the procedure listed in Example 1 with 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.10 g, 0.32 mmol) and 4-chloro-2-cyclopropylpyrimidine (0.05 g, 0.32 mmol) as the starting materials.

Sources & evidence

ORD record
ord-6a7c4806a3124ff5a68afdec47468a09
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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