HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-cyclopropylpyrimidine → 2-[(2-Cyclopropylpyrimidin-4-yl)amino]-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-cyclopropylpyrimidine | HCID 24903713 | — |
| Reactant | 2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide | HCID 59525619 | — |
| Product | 2-[(2-Cyclopropylpyrimidin-4-yl)amino]-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide | HCID 59525742 | — |
Reaction Steps
The title compound was prepared by using the procedure listed in Example 1 with 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.10 g, 0.32 mmol) and 4-chloro-2-cyclopropylpyrimidine (0.05 g, 0.32 mmol) as the starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367706B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-6a7c4806a3124ff5a68afdec47468a09 |
| Source note | uspto-grants-2013_02 |