4-Chloro-2-(2-trimethylsilanyl-ethoxy)-pyrimidine → 5-[4-(1-Cyano-1-methylethyl)phenyl]-2-({2-[2-(trimethylsilyl)ethoxy]pyrimidin-4-yl}amino)thiophene-3-carboxamide
Reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([C:19]#[N:20])([CH3:18])[CH3:17])=[CH:12][CH:11]=2)=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Cl[C:22]1[CH:27]=[CH:26][N:25]=[C:24]([O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])[N:23]=1>>[C:19]([C:16]([C:13]1[CH:14]=[CH:15][C:10]([C:4]2[S:3][C:2]([NH:1][C:26]3[CH:27]=[CH:22][N:23]=[C:24]([O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])[N:25]=3)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=2)=[CH:11][CH:12]=1)([CH3:18])[CH3:17])#[N:20]Participants
3
Procedure
The title compound was prepared according to the general procedure in Example 1 using 2-amino-5-[4-(1-cyano-1-methylethyl)phenyl]thiophene-3-carboxamide (100 mg, 0.350 mmol) and 4-chloro-2-[2-(trimethylsilyl)ethoxy]pyrimidine (81 mg, 0.350 mmol) (see J. Het. Chem., 1994, 989-995) as the starting materials.
Sources & evidence
- ORD record
- ord-c9ea3f1fc99f4173ad84e981b3510efa
- Source dataset
- uspto-grants-2013_02
- Patent number
- US08367706B2
Reaction notes
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