4-Chloro-2-(2-trimethylsilanyl-ethoxy)-pyrimidine → 5-[4-(1-Cyano-1-methylethyl)phenyl]-2-({2-[2-(trimethylsilyl)ethoxy]pyrimidin-4-yl}amino)thiophene-3-carboxamide

Participants

Reaction Steps

The title compound was prepared according to the general procedure in Example 1 using 2-amino-5-[4-(1-cyano-1-methylethyl)phenyl]thiophene-3-carboxamide (100 mg, 0.350 mmol) and 4-chloro-2-[2-(trimethylsilyl)ethoxy]pyrimidine (81 mg, 0.350 mmol) (see J. Het. Chem., 1994, 989-995) as the starting materials.

Provenance & Evidence