5-{[Tert-butyl(dimethyl)silyl]ethynyl}-2-nitrothiophene-3-carboxamide → 2-Amino-5-{[tert-butyl(dimethyl)silyl]ethynyl}thiophene-3-carboxamide

Participants

Reaction Steps

To 5-{[tert-butyl(dimethyl)silyl]ethynyl}-2-nitrothiophene-3-carboxamide (100 mg, 0.32 mmol) in MeOH (8.0 mL) was added 3% Pt/C doped with 0.6% V (21 mg, 3.2 μmol). The reaction was stirred under an H2 balloon at room temperature for 2 h. The solution was diluted with MeOH, filtered through Celite, combined with silica gel, and evaporated. Flash chromatography (dry load, 25-100% EtOAc/hexanes) afforded the title compound as a tan solid.

Provenance & Evidence