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HRID386139

反应详情

EQUATION

反应方程式

HRID 386139 的结构方程式

REACTANTS

反应物

1
结构：CC(C)(C)[Si](C)(C)C#Cc1cc(C(N)=O)c([N+](=O)[O-])s1
HCID59526386

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)[Si](C)(C)C#Cc1cc(C(N)=O)c(N)s1
HCID59526335

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pt]
催化剂HCID23939

Platinum

Pt

结构：CO
溶剂HCID887

Methanol

CH4O

2 次

PROCEDURE

实验过程

To 5-{[tert-butyl(dimethyl)silyl]ethynyl}-2-nitrothiophene-3-carboxamide (100 mg, 0.32 mmol) in MeOH (8.0 mL) was added 3% Pt/C doped with 0.6% V (21 mg, 3.2 μmol). The reaction was stirred under an H2 balloon at room temperature for 2 h. The solution was diluted with MeOH, filtered through Celite, combined with silica gel, and evaporated. Flash chromatography (dry load, 25-100% EtOAc/hexanes) afforded the title compound as a tan solid.

WORKUP

后处理

  1. filtrationfiltered through Celite
  2. customevaporated
  3. dry with materialFlash chromatography (dry load, 25-100% EtOAc/hexanes)