(2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride → HCID 58116932, compound

HRID 38614Notes

Reaction equation

HRID 38614 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][C:4]=1[NH:10][C:11]1[C:12]2[C:19]3[CH2:20][CH2:21][NH:22][CH2:23][C:18]=3[S:17][C:13]=2[N:14]=[CH:15][N:16]=1.Cl.[CH3:25][N:26]([CH3:33])[CH2:27]/[CH:28]=[CH:29]/[C:30](O)=[O:31]>>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][C:4]=1[NH:10][C:11]1[C:12]2[C:19]3[CH2:20][CH2:21][N:22]([C:30](=[O:31])/[CH:29]=[CH:28]/[CH2:27][N:26]([CH3:33])[CH3:25])[CH2:23][C:18]=3[S:17][C:13]=2[N:14]=[CH:15][N:16]=1

Participants

3

Reactant 2

HCID 45358758(2E)-4-(Dimethylamino)-2-butenoic acid hydrochlorideHCID 66850362HCID 66850362, compound

Product 1

HCID 58116932HCID 58116932, compound

Procedure

The compound was synthesized in analogy to Example 122 from 4-chloro-3-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride from Example 70A (100 mg, 0.27 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (63 mg, 0.38 mmol) to yield 17 mg (13%).

Workup

  1. customto yield 17 mg (13%)

Sources & evidence

ORD record
ord-cdb4a5c17bfa46eb9ff8ac4ea33a66eb
Source dataset
uspto-grants-2013_09
Patent number
US08524722B2

Reaction notes

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