(2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride → HCID 58116932, compound

Participants

Reaction Steps

The compound was synthesized in analogy to Example 122 from 4-chloro-3-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride from Example 70A (100 mg, 0.27 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (63 mg, 0.38 mmol) to yield 17 mg (13%).

Provenance & Evidence