反应详情

温度

60 °C

2-{[2-(Morpholin-4-ylmethyl)pyrimidin-4-yl]amino}-5-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,4-triazol-3-yl)thiophene-3-carboxamide (100 mg, 0.19 mmol) was taken up in a mixture of EtOH (3.0 mL) and HCl (2.0 M, 3.00 mL, 6.00 mmol) and heated to 60° C. overnight. The reaction was not complete, so the temperature was raised to 75° C. for 6 h. The resulting suspension was filtered to isolate the title compound as a pale yellow solid (HCl salt).

1. temperatureso the temperature was raised to 75° C. for 6 h
2. filtrationThe resulting suspension was filtered