Hydrochloric Acid → HCID 178513573, compound

HRID 386147Notes

Reaction equation

HRID 386147 reaction equation
[N:1]1([CH2:7][C:8]2[N:13]=[C:12]([NH:14][C:15]3[S:16][C:17]([C:23]4[N:27]=[CH:26][N:25](COCC[Si](C)(C)C)[N:24]=4)=[CH:18][C:19]=3[C:20]([NH2:22])=[O:21])[CH:11]=[CH:10][N:9]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl>CCO>[N:1]1([CH2:7][C:8]2[N:13]=[C:12]([NH:14][C:15]3[S:16][C:17]([C:23]4[N:27]=[CH:26][NH:25][N:24]=4)=[CH:18][C:19]=3[C:20]([NH2:22])=[O:21])[CH:11]=[CH:10][N:9]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59526227HCID 59526227, compound

Product 1

HCID 178513573HCID 178513573, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

2-{[2-(Morpholin-4-ylmethyl)pyrimidin-4-yl]amino}-5-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,4-triazol-3-yl)thiophene-3-carboxamide (100 mg, 0.19 mmol) was taken up in a mixture of EtOH (3.0 mL) and HCl (2.0 M, 3.00 mL, 6.00 mmol) and heated to 60° C. overnight. The reaction was not complete, so the temperature was raised to 75° C. for 6 h. The resulting suspension was filtered to isolate the title compound as a pale yellow solid (HCl salt).

Workup

  1. temperatureso the temperature was raised to 75° C. for 6 h
  2. filtrationThe resulting suspension was filtered

Sources & evidence

ORD record
ord-081177609dba46408511be8d4ada3099
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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