(2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride → HCID 58116837, compound

HRID 38616Notes

Reaction equation

HRID 38616 reaction equation
Cl.[F:2][C:3]1[C:8]([NH:9][C:10]2[C:11]3[C:18]4[CH2:19][CH2:20][NH:21][CH2:22][C:17]=4[S:16][C:12]=3[N:13]=[CH:14][N:15]=2)=[CH:7][C:6]([OH:23])=[C:5]([CH3:24])[CH:4]=1.Cl.[CH3:26][N:27]([CH3:34])[CH2:28]/[CH:29]=[CH:30]/[C:31](O)=[O:32]>>[CH3:26][N:27]([CH3:34])[CH2:28]/[CH:29]=[CH:30]/[C:31]([N:21]1[CH2:20][CH2:19][C:18]2[C:11]3[C:10]([NH:9][C:8]4[C:3]([F:2])=[CH:4][C:5]([CH3:24])=[C:6]([OH:23])[CH:7]=4)=[N:15][CH:14]=[N:13][C:12]=3[S:16][C:17]=2[CH2:22]1)=[O:32]

Participants

3

Reactant 2

HCID 45358758(2E)-4-(Dimethylamino)-2-butenoic acid hydrochlorideHCID 668500154-Fluoro-2-methyl-5-(5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride

Product 1

HCID 58116837HCID 58116837, compound

Procedure

The compound was synthesized in analogy to Example 122 from 4-fluoro-2-methyl-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride from Example 72A (100 mg, 0.27 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (63 mg, 0.38 mmol) to yield 29 mg (24%).

Workup

  1. customto yield 29 mg (24%)

Sources & evidence

ORD record
ord-bd5109e6769c4b75ba58d167132ec18d
Source dataset
uspto-grants-2013_09
Patent number
US08524722B2

Reaction notes

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