HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride → HCID 58116837, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride | HCID 45358758 | — |
| Reactant | 4-Fluoro-2-methyl-5-(5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride | HCID 66850015 | — |
| Product | HCID 58116837 | HCID 58116837 | — |
Reaction Steps
The compound was synthesized in analogy to Example 122 from 4-fluoro-2-methyl-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride from Example 72A (100 mg, 0.27 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (63 mg, 0.38 mmol) to yield 29 mg (24%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524722B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-bd5109e6769c4b75ba58d167132ec18d |
| Source note | uspto-grants-2013_09 |