反应详情

A solution of 3-(4′-Propyl-bicyclohexyl-4-yl)-propionic acid ethyl ester (22.0 g, 70 mmol) in THF (150 ml) is added dropwise to a suspension of lithium-aluminiumhydride (3.25 g, 86 mmol) in THF (250 ml) at reflux temperature. The reaction is heated under reflux for 1 h, cooled and poured onto sat. ammonium chloride solution. The mixture is acidified, extracted with ether and the combined organic layers are washed with brine and dried over sodium sulfate. The solvent is evaporated and the crude product is crystallised from isopropanol to give 3-(4′-propyl-bicyclohexyl-4-yl)-propan-1-ol as colourless crystals.

1. temperatureat reflux temperature
2. temperatureThe reaction is heated
3. temperatureunder reflux for 1 h
4. temperaturecooled
5. extractionextracted with ether
6. washthe combined organic layers are washed with brine
7. dry with materialdried over sodium sulfate
8. customThe solvent is evaporated
9. customthe crude product is crystallised from isopropanol