HCID 59289076, compound → HCID 59289027, compound

HRID 386332Notes

Reaction equation

HRID 386332 reaction equation
[CH2:1]([O:3][C:4](=[O:27])[CH2:5][CH2:6][CH:7]1[CH2:12][CH2:11][CH:10]([CH:13]2[CH2:18][CH2:17][CH:16]([CH:19]3OCC(C)(C)C[O:20]3)[CH2:15][CH2:14]2)[CH2:9][CH2:8]1)[CH3:2]>C1(C)C=CC=CC=1.C(O)=O>[CH2:1]([O:3][C:4](=[O:27])[CH2:5][CH2:6][CH:7]1[CH2:12][CH2:11][CH:10]([CH:13]2[CH2:14][CH2:15][CH:16]([CH:19]=[O:20])[CH2:17][CH2:18]2)[CH2:9][CH2:8]1)[CH3:2]

Participants

4

Reactant 1

HCID 59289076HCID 59289076, compound

Product 1

HCID 59289027HCID 59289027, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 1140TolueneSolvent

Procedure

A solution of 3-[4′-(5,5-Dimethyl-[1,3]dioxan-2-yl)-bicyclohexyl-4-yl]-propionic acid ethyl ester (17 g, 45 mmol) in toluene (200 ml) and formic acid (70 ml) is stirred overnight at 80° C. The solution is washed with water, dried (Na2SO4), concentrated and recrystallised to give 3-(4′-formyl-bicyclohexyl-4-yl)-propionic acid ethyl ester as colourless crystals.

Workup

  1. washThe solution is washed with water
  2. dry with materialdried (Na2SO4)
  3. concentrationconcentrated
  4. customrecrystallised

Sources & evidence

ORD record
ord-7ba0a33256204dcfa02a1731b548c37d
Source dataset
uspto-grants-2013_02
Patent number
US08372307B2

Reaction notes

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