反应详情

A mixture of ethyl 2-(naphthalen-1-yl)-3-oxobutanoate (500 mg, 1.95 mmol) and hydrazine hydrate (0.122 mL, 3.9 mmol) in ethanol (3 mL) was stirred at reflux for 2 hours. The reaction mixture was then cooled to room temperature and concentrated to give compound methyl-4-(naphthalen-1-yl)-1H-pyrazol-3-ol as an oil that solidified upon standing (400 mg, 91%). The crude product was used in next step without further purification.

1. temperatureat reflux for 2 hours
2. concentrationconcentrated