反应详情

Ethyl 5-bromovalerate (2.1 g; 10 mmol; Aldrich) was added to a stirred suspension of sodium azide (1.3 g, 20 mmol; Fisher) in 5 ml dimethylformamide and 5 ml water, and the reaction mixture was heated 12 h at 80° Cs. The reaction was partitioned between diethyl ether (100 ml) and water (100 ml), and the resulting organic layer was washed with water (100 ml) and brine (100 ml), dried over sodium sulfate, and dried in vacuo. Yield: 1.6 g (9.3 mmol, 95% yield).

1. temperaturethe reaction mixture was heated 12 h at 80° Cs
2. customThe reaction was partitioned between diethyl ether (100 ml) and water (100 ml)
3. washthe resulting organic layer was washed with water (100 ml) and brine (100 ml)
4. dry with materialdried over sodium sulfate
5. customdried in vacuo