反应详情

A solution of [3-(2-oxo-imidazolidin-1-yl)-phenyl]-carbamic acid tert-butyl ester (0.88 g, 3.2 mmol) and trifluoroacetic acid (2 ml) in dichloromethane (10 ml) were stirred at room temperature for 5 hours. The reaction was quenched with sodium carbonate (20 ml) and extracted with dichloromethane (3×50 ml). The combined organics were dried (magnesium sulphate) and concentrated in vacuo (0.54 g, 96%). HPLC retention time 1 min. Mass spectrum (ES+) m/z 178 (M+H).

1. customThe reaction was quenched with sodium carbonate (20 ml)
2. extractionextracted with dichloromethane (3×50 ml)
3. dry with materialThe combined organics were dried (magnesium sulphate)
4. concentrationconcentrated in vacuo (0.54 g, 96%)