Acetic Anhydride → 8-(4-Acetamido-2-dimethylamino-phenyl)-purin-6-one

HRID 3865Notes

Reaction equation

HRID 3865 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:16]=[C:15]3[C:10](=[N:11][CH:12]=[N:13][C:14]3=[O:17])[N:9]=2)=[C:4]([N:18]([CH3:20])[CH3:19])[CH:3]=1.[C:21](OC(=O)C)(=[O:23])[CH3:22]>>[C:21]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:16]=[C:15]3[C:10](=[N:11][CH:12]=[N:13][C:14]3=[O:17])[N:9]=2)=[C:4]([N:18]([CH3:20])[CH3:19])[CH:3]=1)(=[O:23])[CH3:22]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 201532408-(4-Amino-2-dimethylamino-phenyl)purin-6-one

Product 1

HCID 201533548-(4-Acetamido-2-dimethylamino-phenyl)-purin-6-one

Procedure

A quantity of 0.6 gm of 8-(4-amino-2-dimethylamino-phenyl)purin-6-one is heated to 150° C. in 5 ml of acetic anhydride for one hour. The mixture is evaporated to dryness in vacuo and recrystallized from acetone/ether.

Workup

  1. customThe mixture is evaporated to dryness in vacuo
  2. customrecrystallized from acetone/ether

Sources & evidence

ORD record
ord-639397261a4c4c98b76a12db25b2c876
Source dataset
uspto-grants-1988_02
Patent number
US04722929

Reaction notes

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