HRID38661

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cc(OP(=O)(OCc2ccccc2)OCc2ccccc2)cc(-c2cc(OP(=O)(OCc3ccccc3)OCc3ccccc3)c3cc4c(cc3n2)OCO4)c1

HCID56646750

未命名化合物

PRODUCTS

生成物

结构：COc1cc(OP(=O)(OCc2ccccc2)OCc2ccccc2)cc(C2=Nc3cc4c(cc3C(=O)C2)OCO4)c1

HCID66659199

未命名化合物

收率 45%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

CONDITIONS

反应条件

温度: 25 °C

PROCEDURE

实验过程

A suspension of 0.92 g (1.11 mmol) of 167 in 100 mL of methanol was stirred at 25° C. for 48 h. The precipitates were collected and purified by column chromatography (SiO2, EtOAc) to give 168.

WORKUP

后处理

customThe precipitates were collected
custompurified by column chromatography (SiO2, EtOAc)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6ff94a40cbe94c12bb7d85c1cae3b3fd
来源数据集: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08524740B2
来源说明: uspto-grants-2013_09

反应 SMILES

P([O:19][C:20]1[C:29]2[C:24](=[CH:25][C:26]3[O:32][CH2:31][O:30][C:27]=3[CH:28]=2)[N:23]=[C:22]([C:33]2[CH:38]=[C:37]([O:39][CH3:40])[CH:36]=[C:35]([O:41][P:42]([O:52][CH2:53][C:54]3[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=3)([O:44][CH2:45][C:46]3[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=3)=[O:43])[CH:34]=2)[CH:21]=1)(OCC1C=CC=CC=1)(OCC1C=CC=CC=1)=O>CO>[CH2:53]([O:52][P:42]([O:41][C:35]1[CH:34]=[C:33]([C:22]2[CH2:21][C:20](=[O:19])[C:29]3[C:24](=[CH:25][C:26]4[O:32][CH2:31][O:30][C:27]=4[CH:28]=3)[N:23]=2)[CH:38]=[C:37]([O:39][CH3:40])[CH:36]=1)([O:44][CH2:45][C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)=[O:43])[C:54]1[CH:55]=[CH:56][CH:57]=[CH:58][CH:59]=1