反应详情

温度

25 °C

To a solution of quinolin-6-ylamine (503 mg, 3.49 mmol) in dichloromethane (17 mL) and methanol (8.6 mL) was added tetra-n-butylammonium tribromide (1.68 g, 3.49 mmol). The mixture was stirred at 25° C. for 90 minutes, and then 10 5 mL of aqueous sodium thiosulfate was added. The mixture was extracted with dichloromethane, and the combined extracts were washed with water, dried (Na2SO4), filtered and concentrated to dryness under reduced pressure. Purification by flash column (hexanes/ethylacetate gradient) gave 5-bromo-quinolin-6-ylamine (246 mg, 32%).

1. extractionThe mixture was extracted with dichloromethane
2. washthe combined extracts were washed with water
3. dry with materialdried (Na2SO4)
4. filtrationfiltered
5. concentrationconcentrated to dryness under reduced pressure
6. customPurification by flash column (hexanes/ethylacetate gradient)