Ethanol → Ethyl 3-bromo-4-methoxyphenylacetate

HRID 38683Notes

Reaction equation

HRID 38683 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[CH3:14][CH2:15]O>Cl>[CH2:14]([O:12][C:11](=[O:13])[CH2:10][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([Br:1])[CH:3]=1)[CH3:15]

Participants

4

Reactant 2

HCID 702EthanolHCID 1366153-Bromo-4-methoxyphenylacetic acid

Product 1

HCID 57419861Ethyl 3-bromo-4-methoxyphenylacetate

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidCatalyst

Conditions

Temperature
80 °C

Procedure

3-Bromo-4-methoxyphenylacetic acid (4.1 g, 16.7 mmol) in EtOH (100 mL) was treated with concentrated HCl (2 drops) and heated to 80° C. for 3 days. After cooling to room temperature, the mixture was concentrated to give the title compound.

Workup

  1. temperatureAfter cooling to room temperature
  2. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-030b5dbf3810429cbd2c12d01eaaf0e3
Source dataset
uspto-grants-2013_09
Patent number
US08524748B2

Reaction notes

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