Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → HCID 178526361, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 3-Bromo-4-fluoroaniline | HCID 2779286 | — |
| 반응물 | N-Hydroxy-4-morpholin-4-yl-1,2,5-oxadiazole-3-carboximidoyl chloride | HCID 136335829 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | HCID 178526361 | HCID 178526361 | 48.7% |
반응 단계
A solution of N-Hydroxy-4-morpholin-4-yl-1,2,5-oxadiazole-3-carboximidoyl chloride (40 mg, 0.17 mmol) and 3-bromo-4-fluoroaniline (49 mg, 0.26 mmol) in ethanol (1 mL) was treated with a solution of N,N-diisopropylethylamine (45 μL, 0.26 mmol) in acetonitrile (1 mL) and stirred for 62 h. The reaction mixture was purified by preparative HPLC to give the desired product (32 mg, 48%). LCMS for C13H14ClFN5O3 (M+H)+: m/z=386.0, 388.0.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08372870B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-932212d5579248cb88c02336656c6d56 |
| 출처 메모 | uspto-grants-2013_02 |