HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 38688Generated: October 29, 2026
Lithium Hydroxide → (6-Methoxy-2'-phenylsulfanylmethyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid
https://huagongshe.com/reaction/38688
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | (6-Methoxy-2'-phenylsulfanylmethyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester | HCID 67432230 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (6-Methoxy-2'-phenylsulfanylmethyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid | HCID 45136825 | — |
Reaction Steps
To (6-methoxy-2′-phenylsulfanylmethyl-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester (0.24 mmol) in MeOH was added lithium hydroxide (a spatula tip), and the reaction was stirred at 65° C. overnight. After acidic work-up, the crude material was purified by preparative HPLC to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08524748B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-a4b5a62365aa4525a659fe95236ee421 |
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| Source note | uspto-grants-2013_09 |
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