Lithium Hydroxide → (6-Methoxy-2'-phenylsulfanylmethyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid

HRID 38688Notes

Reaction equation

C([O:3][C:4](=[O:32])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:15]=2[CH2:24][S:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)C.[OH-].[Li+]>CO>[CH3:13][O:12][C:9]1[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:21])[F:22])=[CH:16][C:15]=2[CH2:24][S:25][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)=[CH:7][C:6]([CH2:5][C:4]([OH:32])=[O:3])=[CH:11][CH:10]=1

Participants

Conditions

Temperature: 65 °C

Procedure

To (6-methoxy-2′-phenylsulfanylmethyl-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester (0.24 mmol) in MeOH was added lithium hydroxide (a spatula tip), and the reaction was stirred at 65° C. overnight. After acidic work-up, the crude material was purified by preparative HPLC to give the title compound.

Workup

customAfter acidic work-up, the crude material was purified by preparative HPLC

Sources & evidence

ORD record: ord-a4b5a62365aa4525a659fe95236ee421
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08524748B2

Reaction notes

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