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HRID386926

反应详情

EQUATION

反应方程式

HRID 386926 的结构方程式

REACTANTS

反应物

1
结构：COc1ccc2cc([C@H](C)C(=O)O)ccc2c1
HCID156391

Naproxen

C14H14O3

PRODUCTS

生成物

1
结构：CC(C(=O)O)c1ccc2cc(O)ccc2c1
HCID162920

Desmethylnaproxen

C13H12O3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Br
溶剂HCID260

Hydrogen Bromide

BrH

PROCEDURE

实验过程

A mixture of Naproxen (500 grams, 2.774 mmol) and 48% HBr (1500 ml) was refluxed for 10 Hours, poured onto ice water (3000 ml) and stirred for 30 minutes. Crude 36 was filtered, dried (380 grams, 81%) and used as such for next stage.

WORKUP

后处理

  1. temperaturewas refluxed for 10 Hours
  2. additionpoured onto ice water (3000 ml)
  3. filtrationCrude 36 was filtered
  4. customdried (380 grams, 81%)