反应详情

温度

150 °C

An amount of 4.5 gm of powdered potassium hydroxide is dissolved in 70 ml of benzyl alcohol, and then 7.2 gm of 8-(2-methoxy-4-benzyloxy-phenyl)-2-chloro-purine are added. The mixture is heated to 150° C. for three hours, cooled, and filtered, the filtrate is mixed with ether, and the precipitate obtained is purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:2.5)].

1. temperaturecooled
2. filtrationfiltered
3. additionthe filtrate is mixed with ether
4. customthe precipitate obtained
5. customis purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:2.5)]