Methyl 2-(4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate → {2'-[(Benzyl-ethyl-carbamoyloxy)-methyl]-6-fluoro-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester

HRID 38700Notes

Reaction equation

HRID 38700 reaction equation
[CH3:1][O:2][C:3](=[O:21])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([F:11])=[C:7](B2OC(C)(C)C(C)(C)O2)[CH:6]=1.Br[C:23]1[CH:42]=[CH:41][C:40]([C:43]([F:46])([F:45])[F:44])=[CH:39][C:24]=1[CH2:25][O:26][C:27](=[O:38])[N:28]([CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[CH2:29][CH3:30]>>[CH3:1][O:2][C:3](=[O:21])[CH2:4][C:5]1[CH:6]=[C:7]([C:23]2[CH:42]=[CH:41][C:40]([C:43]([F:44])([F:45])[F:46])=[CH:39][C:24]=2[CH2:25][O:26][C:27](=[O:38])[N:28]([CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:29][CH3:30])[C:8]([F:11])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 46739456Methyl 2-(4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetateHCID 67430273Benzyl-ethyl-carbamic acid 2-bromo-5-trifluoromethyl-benzyl ester

Product 1

HCID 67430680{2'-[(Benzyl-ethyl-carbamoyloxy)-methyl]-6-fluoro-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 15, Step 3, using the following starting materials: [4-fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid methyl ester and benzyl-ethyl-carbamic acid 2-bromo-5-trifluoromethyl-benzyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-7884ef070ce649e9aa6596086abf5c3b
Source dataset
uspto-grants-2013_09
Patent number
US08524748B2

Reaction notes

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