Hydrochloric Acid → Methyl 2-(3-bromo-4-methoxyphenyl)acetate

HRID 38701Notes

Reaction equation

HRID 38701 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].Cl.[CH3:15]O>>[CH3:15][O:12][C:11](=[O:13])[CH2:10][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([Br:1])[CH:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 1366153-Bromo-4-methoxyphenylacetic acid

Product 1

HCID 12717575Methyl 2-(3-bromo-4-methoxyphenyl)acetate

Procedure

To 3-bromo-4-methoxyphenylacetic acid (1.0 g, 4.1 mmol) in MeOH (20 mL) was added HCl (4N in 1,4-dioxane; 5 mL, 20 mmol), and the reaction was refluxed overnight. The mixture was concentrated to give the title compound.

Workup

  1. temperaturethe reaction was refluxed overnight
  2. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-8270844e8c9c4a2aa36d4cea219762d2
Source dataset
uspto-grants-2013_09
Patent number
US08524748B2

Reaction notes

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