1-(2-Fluorophenyl)piperazine → HCID 68557187, compound

HRID 387152Notes

Reaction equation

HRID 387152 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([CH2:13][CH2:14][CH:15]=O)=[CH:11][C:10]([CH2:17][CH2:18][CH3:19])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[F:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1.[BH3-]C#N.[Na+]>>[F:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[N:27]1[CH2:32][CH2:31][N:30]([CH2:15][CH2:14][CH2:13][C:12]2[N:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[N:9]=[C:10]([CH2:17][CH2:18][CH3:19])[CH:11]=2)[CH2:29][CH2:28]1

Participants

4

Reactant 3

HCID 705291-(2-Fluorophenyl)piperazineHCID 5003444Sodium cyanoborohydrideHCID 86639933HCID 86639933, compound

Product 1

HCID 68557187HCID 68557187, compound

Procedure

91.87 mg (46.19%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-(3-chlorophenyl)-3-propyl-1H-pyrazol-5-yl)propanal (124.75 mg, 0.451 mmol), 1-(2-fluorophenyl)piperazine (92 mL, 0.586 mmol), and NaCNBH3 (85.02 mg, 1.353 mmol).

Workup

  1. custom91.87 mg (46.19%) of target compound was obtained

Sources & evidence

ORD record
ord-435a0aed417d4166b1aae04d5cb33992
Source dataset
uspto-grants-2013_02
Patent number
US08372844B2

Reaction notes

Loading…