1-(2-Fluorophenyl)piperazine → HCID 68557424, compound

HRID 387153Notes

Reaction equation

HRID 387153 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13]([CH2:14][CH2:15][CH:16]=O)=[CH:12][C:11]([CH2:18][CH2:19][CH3:20])=[N:10]2)=[CH:5][CH:4]=1.[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1.[BH3-]C#N.[Na+]>>[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][N:31]([CH2:16][CH2:15][CH2:14][C:13]2[N:9]([C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[N:10]=[C:11]([CH2:18][CH2:19][CH3:20])[CH:12]=2)[CH2:30][CH2:29]1

Participants

4

Reactant 3

HCID 705291-(2-Fluorophenyl)piperazineHCID 5003444Sodium cyanoborohydrideHCID 86639934HCID 86639934, compound

Product 1

HCID 68557424HCID 68557424, compound

Procedure

114 mg (66.0%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-(4-methoxyphenyl)-3-propyl-1H-pyrazol-5-yl)propanal (107.73 mg, 0.396 mmol), 1-(2-fluorophenyl)piperazine (82.22 mL, 0.514 mmol), and NaCNBH3 (74.58 mg, 1.187 mmol).

Workup

  1. custom114 mg (66.0%) of target compound was obtained

Sources & evidence

ORD record
ord-a769f9ef90ab4705918e8050e03fc2c5
Source dataset
uspto-grants-2013_02
Patent number
US08372844B2

Reaction notes

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