1-(2-Fluorophenyl)piperazine → HCID 68556840, compound

HRID 387155Notes

Reaction equation

HRID 387155 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH2:13][CH2:14][CH:15]=O)=[CH:11][C:10]([CH2:17][CH2:18][CH3:19])=[N:9]2)=[CH:4][CH:3]=1.[F:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1.[BH3-]C#N.[Na+]>>[F:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[N:27]1[CH2:32][CH2:31][N:30]([CH2:15][CH2:14][CH2:13][C:12]2[N:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)[N:9]=[C:10]([CH2:17][CH2:18][CH3:19])[CH:11]=2)[CH2:29][CH2:28]1

Participants

4

Reactant 3

HCID 705291-(2-Fluorophenyl)piperazineHCID 5003444Sodium cyanoborohydrideHCID 86639936HCID 86639936, compound

Product 1

HCID 68556840HCID 68556840, compound

Procedure

119 mg (65.0%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-(4-fluorophenyl)-3-propyl-1H-pyrazol-5-yl)propanal (112.3 mg, 0.431 mmol), 1-(2-fluorophenyl)piperazine (102.22 mL, 0.647 mmol), and NaCNBH3 (274.29 mg, 1.294 mmol).

Workup

  1. custom119 mg (65.0%) of target compound was obtained

Sources & evidence

ORD record
ord-f3d3659e06f44f80a1a30b0195abd043
Source dataset
uspto-grants-2013_02
Patent number
US08372844B2

Reaction notes

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