1-(2-Fluorophenyl)piperazine → HCID 68558562, compound

HRID 387159Notes

Reaction equation

[CH2:1]([N:8]1[C:12]([CH2:13][CH2:14][CH:15]=O)=[CH:11][C:10]([CH2:17][CH2:18][CH3:19])=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>>[F:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[N:27]1[CH2:32][CH2:31][N:30]([CH2:15][CH2:14][CH2:13][C:12]2[N:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[N:9]=[C:10]([CH2:17][CH2:18][CH3:19])[CH:11]=2)[CH2:29][CH2:28]1

Participants

Reactant 3

HCID 705291-(2-Fluorophenyl)piperazine

HCID 5049666Sodium triacetoxyborohydride

HCID 86639940HCID 86639940, compound

Product 1

HCID 68558562HCID 68558562, compound

Procedure

86 mg (84.5%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-benzyl-3-propyl-1H-pyrazol-5-yl)propanal (62 mg, 0.242 mmol), 1-(2-fluorophenyl)piperazine (76 mL, 0.484 mmol), and NaBH(OAc)3 (198 mg, 0.936 mmol).

Workup

custom86 mg (84.5%) of target compound was obtained

Sources & evidence

ORD record: ord-2ed6a1da6af648fbac7ad9c3fb0e0f0b
Source dataset: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08372844B2

Reaction notes

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