1-(2-Fluorophenyl)piperazine → HCID 68560750, compound

HRID 387160Notes

Reaction equation

HRID 387160 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([N:10]2[C:14]([CH2:15][CH2:16][CH:17]=O)=[CH:13][C:12]([CH2:19][CH2:20][CH3:21])=[N:11]2)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[F:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>>[F:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[N:29]1[CH2:34][CH2:33][N:32]([CH2:17][CH2:16][CH2:15][C:14]2[N:10]([C:6]3[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=3)[N:11]=[C:12]([CH2:19][CH2:20][CH3:21])[CH:13]=2)[CH2:31][CH2:30]1

Participants

4

Reactant 3

HCID 705291-(2-Fluorophenyl)piperazineHCID 5049666Sodium triacetoxyborohydrideHCID 86639941HCID 86639941, compound

Product 1

HCID 68560750HCID 68560750, compound

Procedure

67 mg (83.6%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-(3-nitrophenyl)-3-propyl-1H-pyrazol-5-yl)propanal (51 mg, 0.178 mmol), 1-(2-fluorophenyl)piperazine (42 mL, 0.266 mmol), and NaBH(OAc)3 (198 mg, 0.936 mmol).

Workup

  1. custom67 mg (83.6%) of target compound was obtained

Sources & evidence

ORD record
ord-0c3f769adb1c4cf5a020a18603df896e
Source dataset
uspto-grants-2013_02
Patent number
US08372844B2

Reaction notes

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