1-(2-Fluorophenyl)piperazine → HCID 68557096, compound

HRID 387165Notes

Reaction equation

HRID 387165 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([CH2:13][CH2:14][CH:15]=O)=[CH:11][C:10]([CH2:17][CH2:18][CH2:19][CH3:20])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>>[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][N:31]([CH2:15][CH2:14][CH2:13][C:12]2[N:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[N:9]=[C:10]([CH2:17][CH2:18][CH2:19][CH3:20])[CH:11]=2)[CH2:30][CH2:29]1

Participants

4

Reactant 3

HCID 705291-(2-Fluorophenyl)piperazineHCID 5049666Sodium triacetoxyborohydrideHCID 86639944HCID 86639944, compound

Product 1

HCID 68557096HCID 68557096, compound

Procedure

312 mg (84.2%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-(3-chlorophenyl)-3-butyl-1H-pyrazol-5-yl)propanal (236.75 mg, 0.814 mmol), 1-(2-fluorophenyl)piperazine (192.9 mL, 1.221 mmol), and NaBH(OAc)3 (198 mg, 0.936 mmol).

Workup

  1. custom312 mg (84.2%) of target compound was obtained

Sources & evidence

ORD record
ord-b43e8daaced54ddd9304fe47c421bf1f
Source dataset
uspto-grants-2013_02
Patent number
US08372844B2

Reaction notes

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