1-(2-Fluorophenyl)piperazine → HCID 68162358, compound

HRID 387172Notes

Reaction equation

HRID 387172 reaction equation
[CH2:1]([N:8]1[C:12]([CH2:13][CH2:14][CH:15]=O)=[CH:11][C:10]([CH2:17][CH2:18][CH2:19][CH3:20])=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>>[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][N:31]([CH2:15][CH2:14][CH2:13][CH:12]2[N:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[N:9]=[C:10]([CH2:17][CH2:18][CH2:19][CH3:20])[CH2:11]2)[CH2:30][CH2:29]1

Participants

4

Reactant 3

HCID 705291-(2-Fluorophenyl)piperazineHCID 5049666Sodium triacetoxyborohydrideHCID 86639951HCID 86639951, compound

Product 1

HCID 68162358HCID 68162358, compound

Procedure

180 mg (84.2%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-benzyl-3-butyl-1H-pyrazol-5-yl)propanal (133 mg, 0.492 mmol), 1-(2-fluorophenyl)piperazine (155 mL, 0.984 mmol), and NaBH(OAc)3 (198 mg, 0.936 mmol).

Workup

  1. custom180 mg (84.2%) of target compound was obtained

Sources & evidence

ORD record
ord-5e7eddbeace646dda11bcd120262029e
Source dataset
uspto-grants-2013_02
Patent number
US08372844B2

Reaction notes

Loading…