反应详情

温度

2.5 °C

To an ice-cold stirred suspension of 4-nitrophenacyl bromide (80 g, 0.33 mol) in methanol (800 mL) was added sodium borohydride (13.64 g, 0.36 mol) in small portions. After stirring for 2 h at 0-5° C., potassium carbonate (45.20 g, 0.33 mol) was added in small portions at the same temperature. The suspension was stirred for 18 h at room temperature, diluted with brine (600 mL) and extracted with diethyl ether (600 mL, 500 mL), the combined organic layers were dried over sodium sulfate, filtered and evaporated. The title compound (54.87 g, 0.33 mmol, 100%) was obtained as a pale yellow solid.

1. stirringThe suspension was stirred for 18 h at room temperature
2. extractionextracted with diethyl ether (600 mL, 500 mL)
3. dry with materialthe combined organic layers were dried over sodium sulfate
4. filtrationfiltered
5. customevaporated