反应详情

A solution of di-tert-butylcarbonate (427.1 g, 1.96 mol) in CH2Cl2 (500 mL) was added dropwise at room temperature to a solution of indoline (212 g 1.78 mol) in CH2Cl2 (1000 mL). A solution of NaOH (85.3 g, 2.13 mol) in water (500 mL) was then added dropwise and the mixture was stirred overnight. The layers were separated and the organic layer was washed with 5% NaOH, brine and dried over Na2SO4. The organic layer was concentrated under reduced pressure and the crude product was crystallized with petroleum ether, giving 324 g (68%) of the title compound.

1. customThe layers were separated
2. washthe organic layer was washed with 5% NaOH, brine
3. dry with materialdried over Na2SO4
4. concentrationThe organic layer was concentrated under reduced pressure
5. customthe crude product was crystallized with petroleum ether