反应详情

Methyl 5-bromo-1H-indole-7-carboxylate (5 g, 19.7 mmol) was dissolved in methanol (200 mL) and a solution of lithium hydroxide (0.99 g, 41 mmol) in water (10 mL) was added. The mixture was heated at reflux for 50 hours. The methanol was removed in vacuo and the residue diluted with aqueous hydrochloric acid (2 M). The resulting precipitate was filtered off and dried in a heated vacuum pistol to give 4.7 g (99%) of the title compound as a beige solid.

1. temperatureThe mixture was heated
2. temperatureat reflux for 50 hours
3. customThe methanol was removed in vacuo
4. additionthe residue diluted with aqueous hydrochloric acid (2 M)
5. filtrationThe resulting precipitate was filtered off
6. customdried in a heated vacuum pistol