2-Methyl-3-butyn-2-ol → HCID 11687175, compound

HRID 387406Notes

Reaction equation

HRID 387406 reaction equation
[CH2:1]([N:8]=[N+:9]=[N-:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:11][C:12]([OH:16])([C:14]#[CH:15])[CH3:13]>C[C-]1C(C)=C(C)C(C)=C1C.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.Cl[Ru+].C1C=CC=CC=1>[CH2:1]([N:8]1[C:14]([C:12]([OH:16])([CH3:13])[CH3:11])=[CH:15][N:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 82582-Methyl-3-butyn-2-olHCID 12152Benzyl azide

Product 1

HCID 11687175HCID 11687175, compound

Reagents, catalysts & solvents 2

HCID 71310463Chlororuthenium(1+) 1,2,3,4,5-pentamethylcyclopenta-2,4-dien-1-ide--triphenylphosphane (1/1/2)CatalystHCID 241BenzeneSolvent

Procedure

Benzyl azide (0.400 g, 3.00 mmol), 2-methyl-3-butyn-2-ol (0.290 ml, 3.00 mmol), Cp*RuCl(PPh3)2 (25 mg, 0.031 mmol). Solvent, benzene; reaction temperature, 80° C.; reaction time, 2.5 hours; yield, 0.63 g (96%). EI-MS: m/z 218 [M+1 ].

Workup

  1. customreaction temperature, 80° C.
  2. customreaction time, 2.5 hours
  3. customyield

Sources & evidence

ORD record
ord-9fe90d8b14dd484cad1eca052c711e6c
Source dataset
uspto-grants-2013_02
Patent number
US08372986B2

Reaction notes

Loading…