反应详情

Methyl 4-hydroxybenzoate (1.52 g, 10.0 mmol) was dissolved in 18 mL of anhydrous dioxane in 10-20 mL microwave vial (Personal Chemistry) and solid Cs2CO3 was added to this solution. The suspension was stirred at ambient temperature for 10 min, then 4-chloro-2,6-diaminopyrimidine (1.45 g, 10.0 mmol) was added. The vial was capped and microwaved at 200° C. for 40 min. Then MeOH was added to dissolve the formed suspension to produce a clear amber solution. The solution was transferred into a round-bottom flask and concentrated down to ca. 20 mL. This solution was purified by silica gel chromatography using 100% ethyl acetate as eluent. The product was additionally re-crystallized from ca. 50 mL of 4:1 mixture of EtOAc/MeOH. The product was filtered, washed with 40 mL of EtOAc, 40 mL of anhydrous Et2O and dried in vacuo to give the title product as a white solid (0.812 g). Yield 31.2%.

1. additionwas added to this solution
2. customThe vial was capped
3. custommicrowaved at 200° C. for 40 min
4. dissolutionto dissolve the formed suspension
5. customto produce a clear amber solution
6. customThe solution was transferred into a round-bottom flask
7. concentrationconcentrated down to ca. 20 mL
8. customThis solution was purified by silica gel chromatography
9. customThe product was additionally re-crystallized from ca. 50 mL of 4:1 mixture of EtOAc/MeOH
10. filtrationThe product was filtered
11. washwashed with 40 mL of EtOAc, 40 mL of anhydrous Et2O
12. customdried in vacuo