反应详情

0.39 g of 5-bromo-2-(2-hydroxyethyl)-3,4-dihydroisoquinolin-1(2H)-one is dissolved under an inert atmosphere in 3 cm3 of dimethylsulfoxide at a temperature close to 20° C. 105 mg of finely ground potassium hydroxide are added. The reaction mixture is stirred for 30 min at a temperature close to 20° C., then 0.108 cm3 of iodomethane is introduced. The stirring is continued for 20 h at a temperature close to 20° C. 30 cm3 of water and 30 cm3 of ethyl ether are added. After decanting, the organic phase is washed with 30 cm3 of a saturated aqueous solution of sodium chloride, dried over magnesium sulfate, filtered and concentrated using a rotary evaporator under reduced pressure (5 kPa). 170 mg of 5-bromo-2-(2-methoxyethyl)-3,4-dihydroisoquinolin-1(2H)-one are obtained in the form of a yellow oil.

1. customclose to 20° C
2. customclose to 20° C.
3. waitThe stirring is continued for 20 h at a temperature
4. customclose to 20° C
5. customAfter decanting
6. washthe organic phase is washed with 30 cm3 of a saturated aqueous solution of sodium chloride
7. dry with materialdried over magnesium sulfate
8. filtrationfiltered
9. concentrationconcentrated
10. customa rotary evaporator under reduced pressure (5 kPa)