反应详情

温度

20 °C

79 mg of N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-(2-methoxyethyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide are dissolved in 2 cm3 of dioxane at a temperature close to 20° C. 1 cm3 of a 4M solution of hydrochloric acid in ethyl ether is added while stirring under argon, at a temperature of 20° C. The reaction mixture is concentrated under vacuum at a temperature of 40° C. 83 mg of N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-(2-methoxyethyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride (1:1) are obtained in the form of a white powder.

1. customclose to 20° C
2. concentrationThe reaction mixture is concentrated under vacuum at a temperature of 40° C