反应详情

温度

85 °C

Phenyl N-(4-(6-cyano-7-(2-methoxyethoxy)-4-quinolyl)oxyphenyl)carbamate (104 mg, 0.228 mmol) was dissolved in dimethylsulfoxide (1 ml), and then 2-aminopyridine (43 mg, 0.457 mmol) was added and the mixture was heated at 85° C. for 3 hours while stirring. After cooling, ethyl acetate and water were added for distribution, and the organic layer was washed with saturated saline and dried over anhydrous sodium sulfate. After filtering off the drying agent and concentrating under reduced pressure, ethyl acetate-hexane was added to the residue and the precipitated crystals were filtered out and dried under reduced pressure to obtain the title compound (86 mg, 0.189 mmol, 82.7%) as white crystals.

1. temperatureAfter cooling
2. washthe organic layer was washed with saturated saline
3. dry with materialdried over anhydrous sodium sulfate
4. filtrationAfter filtering off the drying agent
5. concentrationconcentrating under reduced pressure, ethyl acetate-hexane
6. additionwas added to the residue
7. filtrationthe precipitated crystals were filtered out
8. customdried under reduced pressure