反应详情

4-(4-Amino-3-fluorophenoxy)-6-cyano-7-(2-methoxyethoxy)quinoline (106 mg) and phenyl N-(3-(methylsulfonyl)phenyl)carbamate (96 mg) were added to 5 ml of toluene, and then 0.06 ml of diisopropylethylamine was added and the mixture was heated to reflux for 3 hours. After cooling, ethyl acetate was added and the precipitated insoluble portion was filtered out. The filtrate was concentrated, the resulting residue was dissolved in tetrahydrofuran, toluene was added, and the precipitated solid was filtered out to obtain 13 mg of the title compound as light brown crystals (8% yield).

1. temperaturethe mixture was heated
2. temperatureto reflux for 3 hours
3. temperatureAfter cooling
4. filtrationthe precipitated insoluble portion was filtered out
5. concentrationThe filtrate was concentrated
6. dissolutionthe resulting residue was dissolved in tetrahydrofuran
7. additiontoluene was added
8. filtrationthe precipitated solid was filtered out