Ethyl Acetate → HCID 22936271, compound

HRID 387733Notes

Reaction equation

HRID 387733 reaction equation
[C:1]1([C:7]2[CH:12]=[C:11]([O:13][C:14]3[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=3)[CH:10]=[CH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(OCC)(=O)C.[F:27][C:28]1[CH:33]=[CH:32][C:31]([N:34]=[C:35]=[O:36])=[CH:30][CH:29]=1>CCCCCC>[C:1]1([C:7]2[CH:12]=[C:11]([O:13][C:14]3[CH:15]=[CH:16][C:17]([NH:18][C:35]([NH:34][C:31]4[CH:32]=[CH:33][C:28]([F:27])=[CH:29][CH:30]=4)=[O:36])=[CH:19][CH:20]=3)[CH:10]=[CH:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 709554-Fluorophenyl isocyanateHCID 22936711HCID 22936711, compound

Product 1

HCID 22936271HCID 22936271, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

4-(2-Phenylpyridin-4-yl)oxyaniline (110 mg, 0.42 mM) was added to ethyl acetate (10 ml), and then parafluorophenyl isocyanate (0.56 ml, 4.9 mM) was added while stirring, which was continued for 30 minutes. After adding n-hexane (20 ml) to the reaction solution, the solvent was partially distilled off under reduced pressure and the precipitating solid was filtered out to obtain the target substance (98 mg) as a gray solid.

Workup

  1. distillationthe solvent was partially distilled off under reduced pressure
  2. filtrationthe precipitating solid was filtered out
  3. customto obtain the target substance (98 mg) as a gray solid

Sources & evidence

ORD record
ord-701d11e78f5e4b068b8a08bab6f26154
Source dataset
uspto-grants-2013_02
Patent number
US08372981B2

Reaction notes

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