反应详情

温度

100 °C

The 4-(4-aminophenoxy)-6-cyano-7-(2-methoxyethoxy)quinoline (100 mg) synthesized in Production Example 10 and phenyl N-(3-methylisoxazol-5-yl)carbamate (81 mg) were added to toluene (5 ml), diisopropylethylamine (0.88 ml) was added and the mixture was heated and stirred at 100° C. for 2 hours. After cooling, the precipitated crystals were filtered and washed with an ethyl acetate:toluene (1:1) mixed solvent to obtain the title compound (102 mg).

1. additionwas added
2. temperaturethe mixture was heated
3. temperatureAfter cooling
4. filtrationthe precipitated crystals were filtered
5. washwashed with an ethyl acetate:toluene (1:1)
6. additionmixed solvent