4-Fluorophenyl isocyanate → HCID 22936483, compound

HRID 387802Notes

Reaction equation

HRID 387802 reaction equation
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][C:9]([O:10][C:11]3[CH:17]=[CH:16][C:14]([NH2:15])=[CH:13][CH:12]=3)=[C:4]2[CH:3]=[CH:2]1.[F:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]=[C:26]=[O:27])=[CH:21][CH:20]=1>C(OCC)(=O)C>[F:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH:15][C:14]2[CH:16]=[CH:17][C:11]([O:10][C:9]3[CH:8]=[CH:7][N:6]=[C:5]4[NH:1][CH:2]=[CH:3][C:4]=34)=[CH:12][CH:13]=2)=[O:27])=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 709554-Fluorophenyl isocyanateHCID 22936495HCID 22936495, compound

Product 1

HCID 22936483HCID 22936483, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

After dissolving 90 mg of 4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline in ethyl acetate at room temperature, 0.05 ml of parafluorophenyl isocyanate was added dropwise. The precipitated white crystals were filtered out to obtain 65 mg of the target substance.

Workup

  1. filtrationThe precipitated white crystals were filtered out
  2. customto obtain 65 mg of the target substance

Sources & evidence

ORD record
ord-8461bbbdfac947bda1b2436edab34730
Source dataset
uspto-grants-2013_02
Patent number
US08372981B2

Reaction notes

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