反应详情

4-(2-Cyclobutanecarbonylaminopyridin-4-yl)oxyaniline (130 mg), phenyl N-(2-thiazolyl)carbamate (110 mg) and dimethylsulfoxide (3 ml) were stirred at 80° C. for 30 minutes. Water and ethyl acetate were added to the reaction solution for extraction, and the ethyl acetate layer was washed 5 times with ammonium chloride water and then dried over magnesium sulfate. The drying agent was filtered off, the solvent was distilled off under reduced pressure, ethyl acetate was added to the residue and the precipitated solid was filtered out to obtain 130 mg of the target substance as a light brown solid.

1. washthe ethyl acetate layer was washed 5 times with ammonium chloride water
2. dry with materialdried over magnesium sulfate
3. filtrationThe drying agent was filtered off
4. distillationthe solvent was distilled off under reduced pressure, ethyl acetate
5. additionwas added to the residue
6. filtrationthe precipitated solid was filtered out
7. customto obtain 130 mg of the target substance as a light brown solid